Figure 9.

Modeling alternative double-strand break repair outcomes. Sequence analysis suggests three means of double-strand break (DSB) repair, resulting in evidence of nonhomologous end-joining (NHEJ), reciprocal recombination at large repeats and asymmetrical recombination at intermediate repeats (IRs). Asymmetrical recombination activity at IRs residing on molecules containing gene chimeras can result in substoichiometric shifting (SSS) for relative copy number suppression or amplification of the genomic environment surrounding the chimera.