Evidence of mismatch repair associated with DNA exchange at intermediate repeats in the msh1 mutant. (A) Four polymorphisms differentiate repeat CC-1 from CC-2, three SNPs and one single-nucleotide insertion. The recombinant sequence suggests a process of mismatch repair following heteroduplex formation. (B) List of nonidentical repeats where gene conversion was observed in the recombinant product. Homology between copies of each repeat, as well as the number of corrected SNPs and indels, are indicated. In the case of each repeat listed in the table, mismatches were resolved in favor of the putative donor strand, which were calculated using data from the frequencies of SNPs for each of the repeats in the different generations of the msh1 mutant. No clear pattern (donor vs recipient strand) for indel resolution was observed.
Davila et al. BMC Biology 2011 9:64 doi:10.1186/1741-7007-9-64