Email updates

Keep up to date with the latest news and content from BMC Biology and BioMed Central.

Journal App

google play app store
Open Access Highly Accessed Commentary

Mobile DNA transposition in somatic cells

Haig H Kazazian

Author affiliations

Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Citation and License

BMC Biology 2011, 9:62  doi:10.1186/1741-7007-9-62

Published: 29 September 2011

Abstract

It had been long assumed that almost all insertions of mobile DNA elements occurred during germ-cell development rather than in somatic-cell development, but solid evidence for transposition in somatic cells is now accumulating. To add to this evidence, a recent paper in Mobile DNA reports the somatic transposition of a site-specific retrotransposon, R2, into its insertion site in 28S ribosomal DNA in Drosophila embryos.

See research article: http://www.mobilednajournal.com/content/2/1/11 webcite