Table 2

Site pairs with the highest covariation scores.

Domain family Ref. PDB Structure rank

Natural 2H2C

Synthetic

PDZ 2H2C

SH3

1N5Z

Kinase

1ATP

PRD

Peptide

PRD

Peptide

PRD

Peptide

PRD

Peptide


1

Leu60

Trp119

His88

Thr118

Asn71

Leu7

Tyr229

Ile22

2

Val55

Thr117

Ala37

Thr117

Leu34

Leu7

Leu205

Ile22

3

Ala76

Thr117

Ser39

Thr117

Ile73

Leu7

Leu198

Ile22

4

Pro30

Trp119

Leu60

Thr117

Tyr72

Leu7

Lys189

Ile22

5

Ser98

Trp119

Val92

Thr118

Lys35

Leu7

Phe129

Ile22

6

Ala89

Thr117

Ser57

Thr117

Ser44

Leu7

Glu230

Ile22

7

Gln93

Trp119

Asp58

Thr117

Lys61

Leu7

Glu203

Ile22

8

Asp58

Thr117

Phe34

Thr118

Ile68

Leu7

Ile180

Ile22

9

Ala37

Thr117

Leu20

Leu7

Phe187

Arg19

10

Lys103

Trp119

Ala17

Leu7

Cys199

Ile22


For each site on the PRD, only the site on the peptide with the highest score is shown. For synthetic PDZ domains, only ten sites have variations and among them two were filtered, leaving only eight valid sites. All sites are indexed according to their residue numbers in the reference PDB structures.

Yip et al. BMC Biology 2011 9:53   doi:10.1186/1741-7007-9-53

Open Data