Top-scoring residue pair for the kinase domain. The kinase domain (orange) and the ligand (green) in the PDB structure 1ATP are shown. The second top-scoring residue pair between Leu205 (red) on the domain and position 1 of the binding motif on the ligand (blue), as well as the third top-scoring residue pair between Leu198 (purple) and position 1 of the ligand motif, are in close proximity. The MSA residue Tyr229 involved in the top-scoring pair is also shown (cyan).
Yip et al. BMC Biology 2011 9:53 doi:10.1186/1741-7007-9-53