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Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum

A Taylor Bright12 and Elizabeth A Winzeler23*

Author affiliations

1 Biomedical Sciences Program, University of California, San Diego, 9500 Gillman Dr., La Jolla, CA 92093, USA

2 Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA

3 Department of Cell Biology, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA

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Citation and License

BMC Biology 2011, 9:50  doi:10.1186/1741-7007-9-50

Published: 19 July 2011

Abstract

Long non-coding RNAs (lncRNA) are being increasingly recognized as important regulators of gene expression. A recent paper in Genome Biology reports the identification of a lncRNA family in Plasmodium falciparum, the cause of the most deadly form of malaria, that may help to explain the mechanism of antigenic variation in virulence genes of this important pathogen.

See Research article: http://genomebiology.com/2011/12/6/R56/abstract webcite