Maternal inflammatory response following treatment with saline or LPS doses. LPS treatment (particularly 50 and 150 μg/kg) (A) reduced jumping activity and increased time spent resting in an open-field test at one hour posttreatment, (B) reduced food and water consumption during the first 24 hours posttreatment, (C) reduced body weight at 24 and 48 hours posttreatment (dashed line = preinjection body weight) and (D) increased serum concentration (pg/mL) of inflammatory cytokines posttreatment. Maternal body weight at each 24-hour interval posttreatment is expressed as a percentage of pretreatment body weight, as were food and water consumption during each 24-hour period posttreatment. All values represent means ± standard error of the mean (SEM). *P ≤ 0.05 vs. control (n = 5 to 7 mothers per treatment).
Williams et al. BMC Biology 2011 9:49 doi:10.1186/1741-7007-9-49