Selecting synaptic partners: GRASPing the role of UNC-6/netrin
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BMC Biology 2011, 9:43 doi:10.1186/1741-7007-9-43Published: 10 June 2011
Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.