The most common approach for regulating cell differentiation is based on coaxing cells through sequential stages of differentiation. The top schematic is generic and could be applied to any cell type. The lower paradigm is one that could be used to produce pancreatic β-cells and is taken from the work of Chen et al. . DE, definitive endoderm; EP, endocrine progenitor; PP, pancreatic progenitor.
Rubin and Haston BMC Biology 2011 9:42 doi:10.1186/1741-7007-9-42