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Open Access Commentary

DNA replication: archaeal oriGINS

Stephen D Bell

Author affiliations

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK

Citation and License

BMC Biology 2011, 9:36  doi:10.1186/1741-7007-9-36

Published: 31 May 2011

Abstract

GINS is an essential eukaryotic DNA replication factor that is found in a simplified form in Archaea. A new study in this issue of BMC Biology reveals the first structure of the archaeal GINS complex. The structure reveals the anticipated similarity to the previously determined eukaryotic complex but also has some intriguing differences in the relative disposition of subunit domains.

See research article: http://www.biomedcentral.com/1741-7007/9/28 webcite