Sex, sex chromosomes and gene expression
1 Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beichen West Road, Chaoyang, Beijing, China
2 Department of Ecology and Evolution, University of Chicago, 5801 South Ellis Avenue, Chicago, IL 60637, USA
BMC Biology 2011, 9:30 doi:10.1186/1741-7007-9-30Published: 4 May 2011
The X chromosome has fewer testis-specific genes than autosomes in many species. This bias is commonly attributed to X inactivation in spermatogenesis but a recent paper in BMC Biology provides evidence against X inactivation in Drosophila and proposes that somatic tissue- and testis- but not ovary-specific genes tend not to be located on the X chromosome. Here, we discuss possible mechanisms underlying this bias, including sexual antagonism and dosage compensation.