cEPOR TG mice perform better in the attentional interventions of the 5-choice serial reaction time task (5-CSRTT). (A) Experimental design depicting the standard baseline training steps in 5-CSRTT as well as attentional manipulations. (B,C) cEPOR TG mice showed better attentional performance reflected by shorter reaction times. (D) They displayed less premature responses under lower cognitive demands and (E) were overall faster in progressing through the consecutive training steps. (F,G) Additionally, they were less distractible and more resistant towards irrelevant competing auditory stimuli. WT n = 9 to 11; TG n = 7; mean ± SEM presented; INT = intervention; ITI = inter-trial interval.
Sargin et al. BMC Biology 2011 9:27 doi:10.1186/1741-7007-9-27