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Open Access Commentary

Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

Brendan S Crabb123*, Tania F de Koning-Ward4 and Paul R Gilson13

Author Affiliations

1 Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia

2 The University of Melbourne, Melbourne, Victoria 3010, Australia

3 Monash University, Clayton, Victoria 3800, Australia

4 Deakin University, Waurn Ponds, Victoria 3217, Australia

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BMC Biology 2011, 9:21  doi:10.1186/1741-7007-9-21

Published: 31 March 2011

Abstract

The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identifying and validating new targets for intervention against malaria. But further improvements are still needed for the full power of genome-wide molecular genetic screens to be utilized in this organism.

See research article: http://www.biomedcentral.com/1471-2164/12/155 webcite