Table 4

Significance of the over/under-representation of orthologues of Saccharomyces cerevisiae haploinsufficient (HI) genes on the mating-type chromosomes of ascomycetes and the sex chromosomes of animals

Organism

Predominant lifecycle phase

Mating-type or sex determination system

Orthologues of Saccharomyces cerevisiae HI genes on the mating-type/sex chromosome(s)


P value for over-representation


Saccharomyces cerevisiae

Diploid

Bipolar sexuality

<10-50


Saccharomyces castellii

Diploid

Bipolar sexuality

<10-10


Candida glabrata

Diploid

Bipolar sexuality

<10-10


Saccharomyces kluyveri

Diploid

Bipolar sexuality

<10-12


Kluyveromyces lactis

Haploid

Bipolar sexuality

<10-19


Ashbya gossypii

Haploid

Bipolar sexuality

0.02


Candida albicans

Diploid

Asexual

0.8


Candida dubliniensis

Diploid

Asexual

0.6


Debaryomyces hansenii

Haploid

Bipolar sexuality

0.05


Yarrowia lipolytica

Haploid

Bipolar sexuality

0.002


P value for under-representation


Homo sapiens

Diploid

X/Y

0.02


Pan troglodytes

Diploid

X/Y

0.04


Mus musculus

Diploid

X/Y

0.05


Rattus norvegicus

Diploid

X/Y

0.04


Equus caballus

Diploid

X/Y

0.01


Bos taurus

Diploid

X/Y

0.3


Canis familiaris

Diploid

X/Y

0.02


Gallus gallus

Diploid

Z/W

0.3


Drosophila melanogaster

Diploid

X/Y

0.9


Caenorhabditis elegans

Diploid

X/0

0.02


de Clare et al. BMC Biology 2011 9:15   doi:10.1186/1741-7007-9-15

Open Data