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Open Access Highly Accessed Research article

Haploinsufficiency and the sex chromosomes from yeasts to humans

Michaela de Clare, Pınar Pir and Stephen G Oliver*

Author Affiliations

Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK

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BMC Biology 2011, 9:15  doi:10.1186/1741-7007-9-15

Published: 28 February 2011

Additional files

Additional file 1:

Supplementary Table 1. Table of those genes retained in duplicate in Saccharomyces cerevisiae following the whole-genome duplication, in which at least one of the members of the duplicate pair is haploinsufficient.

Format: XLSX Size: 43KB Download file

Open Data

Additional file 2:

Supplementary Table 2. Table of the 563 human genes predicted, on the basis of the yeast orthologue phenotype, to be haploinsufficient. Genes are listed along with their gene ontology functional annotation, and that of the yeast orthologue.

Format: XLSX Size: 109KB Download file

Open Data

Additional file 3:

Supplementary Table 3. Table of the 104 human genes predicted to be haploinsufficient, which are associated with an inherited disease in the Online Mendelian Inheritance in Man (OMIM) database. Genes are listed along with the related OMIM annotation and OMIM ID.

Format: XLSX Size: 57KB Download file

Open Data