Table 2

Published studies analyzing parental strains using the QTL/Microarray approach in mouse

Phenotype

QTL Mapping

Microarray Experiment

References



Design

Strains

Design

Tissues

Platform


Targeted custom arrays

Arthritis

Congenic

RIIIS/J, B10.RIII

Congenic

Lymph nodes, spleen, paws

Custom

[100]

Obesity

Congenic

SPRET/Ei, C57BL/6J

Parental

Brain, EWAT, GSM, liver

Nimblgen

[101]


Whole-Genome arrays

Alcohol addiction

RIL

HAFT, LAFT

Parental

Brain

MGU74A

[39,102]

Alcohol addiction

RIL

C57BL/6J, DBA/2J

Parental

NAC, PFC, VTA

U74Av2

[103]

Alcohol addiction

Congenic

ISS.ILS.Lore, ISS

Parental

CR

MO430A, MOE430B

[38,104]

Anxiety

Knockout/congenic

B6.129-Il10-/-, C57BL/6J

Congenic

ABR

MOE430

[105]

Anxiety

Database

-

Parental

PFC, VS, TL, PG, CR

Spotted

[106]

Arthritis

AIL

DNA/1J, FVB/N

Parental

Lynph nodes

MOE430A

[107]

Arthritis

AIL

DNA/1J, FVB/N

Parental

Lynph nodes

U430A

[36]

EIAD

F2/RIL

DBA/1, C57BL/6J

Extremes

Lung

NIA15k

[52]

Gallstones

BC

C57L/J, AKR/J

Parental

Liver

Spotted

[108,109]

HSCP

RIL, BC, Congenic

C57BL/6J, DBA/2J

Parental

HSC

Filter

[49]

IBD

BC

B6-Il10-/-, C3H-Il10-/-

Congenic

Colon

U74Av2

[35,110]

Lung injury response

BC

A/J, C57BL/6J

Parental

Lung

Spotted

[29]

Macronutrient intake

Congenic

C57BL/6J, CAST/EiJ

Congenic

Liver, hypothalamus

ABI

[103]

Obesity

Congenic

F-line, L-line

Congenic

Liver, BAT

Spotted

[111]

Obesity

BC

C57BL/6J, SPRET/Pt, SPRET/Ei

Extremes

EWAT

Spotted

[112]

Obesity

F2

DU6i, DBA/2

Parental

EWAT

Mu11k

[47]

Osteoporosis

Congenic

C57BL/6J, CAST/Ei

Congenic

Femur

Spotted

[28,113]

Osteoporosis

RI

C57BL/6J, CAST/Ei

Parental

Kidney

Spotted

[26,45]

Platelet count

F2

CBA/CaH, QSi5

Parental

Liver, kidney, spleen

Spotted/Compugen Mouse 22K

[25]

Pulmonary capacity

F2/BC

C3H/HeJ, JF1/Msf

Parental

Lung

Spotted/Operon

[114]

TR

BC/Introgression

A/J, C57BL/6J

Parental

Liver, kidney, spleen

MG-430v2

[96,115]

Type I diabetes

Congenic

NOD, Idd3, Idd5, Idd3+5, Idd9, B10, B10.H2g7, B10.H2g7Idd3

Congenic

Thymus, Spleen

Affy.Eos.Custom

[116]


Phenotype abbreviations: EIAD: Endotoxin-induced airway disease, HSCP: Hematopoietic stem cells proliferation, IBD: Inflammatory bowel disease, TR: Trypanosomiasis resistance. Tissue abbreviations: ABR: amigdala brain region, BAT: Brown adipose tissue, CR: cerebellum, GSM: gastrocnemius skeletal muscle, HSC: Hematopoietic stem cells, NAC: nucleus accumbens, PFC: Prefrontal cortex, PG: periaqueductal gray, TL: temporal lobe, VS: ventral striatum, VTA: ventral tegmental area. Strain abbreviations: HAFT: High Acute Functional Tolerance, ILS: Inbred Long Sleep, ISL: Inbred Short Sleep, LAFT: Low Acute Functional Tolerance. • Articles included in Table 3.

Verdugo et al. BMC Biology 2010 8:96   doi:10.1186/1741-7007-8-96

Open Data