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Open Access Highly Accessed Research article

Serious limitations of the QTL/Microarray approach for QTL gene discovery

Ricardo A Verdugo14, Charles R Farber2, Craig H Warden3 and Juan F Medrano1*

Author Affiliations

1 Department of Animal Science, University of California Davis. Davis, CA 95616, USA

2 Departments of Medicine, Biochemistry and Molecular Genetics, and Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA

3 Departments of Pediatrics and Neurobiology, Physiology and Behavior, University of California Davis. Davis, CA 95616, USA

4 The Jackson Laboratory, Bar Harbor, ME 04609, USA

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BMC Biology 2010, 8:96  doi:10.1186/1741-7007-8-96

Published: 12 July 2010

Additional files

Additional file 1:

Metadata from QTL/Microarray Studies in Rat and Mouse. Table with one row per each of 37 reviewed studies implementing the QTL/Microarray approach in rodents. Information about experimental design and results was collected. Additional sheets contain description of acronyms and the full list of references.

Format: XLS Size: 249KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

List of phenotypes measured in three congenic strains HG2D, HG11, HG17. The file contains a list, symbol and units of measurement for 16 phenotypes measured in the mice.

Format: PDF Size: 65KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

QTL located within the limits of the donor regions for the HG2D, HG11, and HG17 congenic strains. The file contains a table with interval limits representing a non-redundant set of QTL from the cited references at the highest resolution currently known.

Format: PDF Size: 119KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data