Regulation of lipid droplet turnover by ubiquitin ligases
Cell Biology Program, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, Toronto, Ontario, M5G 1L7 Canada
BMC Biology 2010, 8:94 doi:10.1186/1741-7007-8-94Published: 19 July 2010
Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate.