Genome-wide association studies in Plasmodium species
1 Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
2 Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
BMC Biology 2010, 8:90 doi:10.1186/1741-7007-8-90Published: 13 July 2010
Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity. Geographical substructure in populations may, however, prove a problem in interpreting the results.