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The architecture of RNA polymerase fidelity

Craig D Kaplan

Author Affiliations

Department of Biochemistry and Biophysics, Texas A&M University, TAMU 2128, College Station, TX 77843-2128, USA

BMC Biology 2010, 8:85  doi:10.1186/1741-7007-8-85

Published: 22 June 2010


The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the ways in which the trigger loop may promote selection of correct nucleotide triphosphate substrates.

See research article webcite