Email updates

Keep up to date with the latest news and content from BMC Biology and BioMed Central.

Journal App

google play app store
Open Access Highly Accessed Question and Answer

Video Q&A: Non-coding RNAs and eukaryotic evolution - a personal view

John Mattick

BMC Biology 2010, 8:67  doi:10.1186/1741-7007-8-67

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

Huge genomes and their implications

David Wake   (2010-07-21 16:11)  University of California at Berkeley email

I enjoyed this provocative presentation. It leads to this comment. Lungfish and salamanders have enormous genomes, and in consequence have enormous cells. Because most are small, salamanders have few cells, very few cells by mammalian standards. So it stands to reason that genome growth cannot be neutral because it carries too many negative implications -- slow cell cycle time, organs made of few cells, etc. So, there must be some compensation. What is it? What is the advantage for huge genomes that compensates for the demonstrably negative effects? I think this is a major challenge for genomics. The old "C-value Paradox" still lives!

Competing interests

No competing interests.


Post a comment