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Open Access Commentary

Hidden reach of the micromanagers

Peter S Linsley* and Aimee L Jackson

Author Affiliations

Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA

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BMC Biology 2010, 8:53  doi:10.1186/1741-7007-8-53

Published: 11 May 2010

Abstract

Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens.

See research article http://www.biomedcentral.com/1471-2164/11/175 webcite