Hidden reach of the micromanagers
Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA
BMC Biology 2010, 8:53 doi:10.1186/1741-7007-8-53Published: 11 May 2010
Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens.