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Open Access Highly Accessed Research article

Regeneration and reprogramming compared

Bea Christen1, Vanesa Robles134, Marina Raya1, Ida Paramonov1 and Juan Carlos Izpisúa Belmonte12*

Author Affiliations

1 Center for Regenerative Medicine of Barcelona, 08003 Barcelona, Spain

2 Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA

3 Current address: INDEGSAL, University of León, 24071 León, Spain

4 Current address: Department of Molecular Biology, University of León, 24071, León, Spain

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BMC Biology 2010, 8:5  doi:10.1186/1741-7007-8-5

Published: 20 January 2010

Additional files

Additional file 1:

Figure S1: Statistical relevance of changes in expression levels. Effect sizes (mean ± error) for each regeneration time point on the intercept, for zebrafish pluripotency associated makers and blastema markers. Oblong stage (for pluripotency markers) and 48 hpa (for blastema markers) were the intercept of the models. Asterisks represent statistical differences with the intercept.

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Additional file 2:

Figure S2: Cell divisions in non- regenerating and regenerating fin. Immunohistochemistry of phospho-Histone H3 localization in zebrafish fins: 0 hours (A) and 48 hours (B) post amputation.

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