Table 1

Some examples of targeted therapies for cancer

Drug

Brand name

Drug target*

Cancer types


In clinical use

Bevacizumab

Avastin

VEGF

Colorectal, non-small cell lung, breast, renal


Bortezomib

Velcade

Proteasome

Myeloma, lymphoma


Celecoxib

Onsenal

COX2

Familial adenomatous polyposis


Erlotinib

Tarceva


Gefitinib

Iressa

EGFR

Non-small cell, lung, colorectal, head and neck


Cetuximab

Erbitux


Panitumumab

Vectibix


Imatinib

Gleevec


Dasatinib

Sprycel

BCR-ABL, cKIT, PDGFR

Leukemia, gastrointestinal


Nilotinib

Tasigna


Methotrexate

DHFR

Multiple cancer types


RAD001

Certican

mTOR

Renal


Temirolimus

Toricel


Sorafenib

Nexavar

VEGFR, RAF, cKIT, PDGFR

Renal, hepatic


Sunitinib

Sutent


Topotecan

Hycamtin

Topoisomerase I

Multiple cancer types


Irinotecan

Camptosar


Trastuzumab

Herceptin

ERBB2

Breast


Lapatinib

Tykerb

HER2, EGFR

Breast


Tamoxifen

Nolvadex

ERα

Breast


Exemestane

Aromasin


Anastrozole

Arimidex

Aromatase cytochrome P450

Breast


Letrozole

Femara


Rituximab

MabThera

CD20

Lymphoma


Tositumomab

Bexxar


In development

17AAG

HSP90


ABT-737, ABT-263, Obatoclax

BCL-XL, BCL-2


Alvocidib

CDKs


Olaparib, AG014699

PARP1/2


BEZ235

PI3K


GRN163L

hTERT


Mapatumumab

TRAIL Receptor


Nutlin-3

MDM2


PLX4032

BRAF


GDC-0449

SMO


PF-0477736

CHK1


*Target abbreviations: BCL-2, anti-apoptotic protein BCL-2; BCL-XL, anti-apoptotic protein BCL extra large; BCR-ABL, fusion protein of breakpoint cluster region and tyrosine kinase ABL1; BRAF, protein tyrosine kinase BRAF; CD20, B-cell phosphoprotein CD20; CDKs, cyclin-dependent kinases; CHK1, serine/threonine kinase CHK1; cKIT, tyrosine kinase c-KIT; COX2, cyclooxygenase 2; DHFR, dihydrofolate reductase; EGFR, epidermal growth factor receptor; ERα, estrogen receptor α; HER2, human epidermal growth factor receptor 2; HSP90, heat shock protein 90; hTERT, telomerase reverse transcriptase; MDM2, murine double minute 2; mTOR, mammalian target of rapamycin; PARP1/2, poly(ADP-ribose) polymerase 1/2; PDGFR, platelet-derived growth factor receptor; PI3K, phosphatidylinositol 3-kinase; RAF, small GTPase RAF; SMO, Smoothened; TRAIL receptor, TNF-related apoptosis-inducing ligand receptor; VEGF, vascular endothelial growth factor; VEGFR, VEGF receptor.

Lord and Ashworth BMC Biology 2010 8:38   doi:10.1186/1741-7007-8-38

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