Table 4

Cytotoxicity was assessed by MTT assay in prostate cancer cell lines and normal fibroblasts treated with increasing concentrations (0.01 - 80 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h and 96 h.

SMIP001

SMIP004

Cell line

72 h

96 h

72 h

96 h


LNCaP-WT

47.1

32.7

40

2.4

PC3

~ 80

80

NE

NE

DU145

~ 40

32.5

NE

NE

IMR90

40-80

40-80

NE

NE


NE: No effect.

The data in the table represents the IC50 (μM). NE: No effect.

Rico-Bautista et al. BMC Biology 2010 8:153   doi:10.1186/1741-7007-8-153

Open Data