BMC Biology

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The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

Philipp Kapranov*, Georges St Laurent, Tal Raz, Fatih Ozsolak, C Patrick Reynolds, Poul HB Sorensen, Gregory Reaman, Patrice Milos, Robert J Arceci, John F Thompson* and Timothy J Triche*

BMC Biology 2010, 8:149 doi:10.1186/1741-7007-8-149

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Correction   Open Access Highly Accessed

The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

Philipp Kapranov, Georges St Laurent, Tal Raz, Fatih Ozsolak, C Patrick Reynolds, Poul HB Sorensen, Gregory Reaman, Patrice Milos, Robert J Arceci, John F Thompson, Timothy J Triche BMC Biology 2011, 9:86 (20 December 2011)

Research   Open Access Highly Accessed

Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer

Ana C Tahira, Márcia S Kubrusly, Michele F Faria, Bianca Dazzani, Rogério S Fonseca, Vinicius Maracaja-Coutinho, Sergio Verjovski-Almeida, Marcel CC Machado, Eduardo M Reis Molecular Cancer 2011, 10:141 (13 November 2011)

Editorial   Open Access Highly Accessed

The noncoding universe

Kester Jarvis, Miranda Robertson BMC Biology 2011, 9:52 (28 July 2011)

In an editorial revisiting the controversy on the extent of the noncoding transcriptome, BMC Biology concludes that the bioinformatic facts are becoming clearer but their biological meaning remains obscure.

Review   Free Highly Accessed

The properties and applications of single-molecule DNA sequencing

John F Thompson, Patrice M Milos Genome Biology 2011, 12:217 (24 February 2011)

Single-molecule sequencing works directly from biological samples and generates very long reads, making it well suited for diagnostic and clinical applications.