Zebrafish models of the immune response: taking it on the ChIn
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BMC Biology 2010, 8:148 doi:10.1186/1741-7007-8-148Published: 22 December 2010
The zebrafish is proving to be an extremely versatile new experimental model for unraveling the mysteries of innate immunity and has considerable promise as a system for the identification of novel modulators of this crucial biological process. A rate-limiting factor, however, is the mechanical stimulus required to induce the inflammatory response. A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field.