Table 8

Duplication triads and patterns of expression subfunctionalisation and neofunctionalisationa

Triad expression

Tetrapoda and younger

Chordata

2ROs

Evolutionary interpretation


b: b &b

0

6

56

Ancestral expression conservation (b)

b: nb & b

5

11

123

Subfunctionalisation through loss of PBE in one duplicate

b: nb & nb

7

12

133

Gain or loss independent of gene duplication

Conservation/sub

0/5 = 0

6/11 = 0.55

56/123 = 0.46

Relative rate of subfunctionalisation

nb: b & b

1

3

18

Gain or loss independent of gene duplication

nb: nb & b

7

11

58

Neofunctionalisation through gain of PBE in one duplicate

nb: nb & nb

12

9

78

Ancestral expression conservation (nb)

Conservation/neo

12/7 = 1.71

9/11 = 0.82

78/58 = 1.34

Relative rate of neofunctionalisation

Sub/neo ratio

5/7 = 0.71

11/11 = 1

123/58 = 2.12

Ratio of sub- to neofunctionalisation


aWe quantified triads depending on brain expression status of a pair of human duplicated genes mapped to unique fly ortholog, depending on timing of duplication ("b" denotes PBE, "nb" denotes lack thereof). PBE, preferential brain expression.

Huminiecki and Heldin BMC Biology 2010 8:146   doi:10.1186/1741-7007-8-146

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