Table 5

Vertebrate-specific cyclin isoformsa

Ancestral bilaterian gene

TreeFam ID

Vertebrate paralogs


Cyclin A

TF101002

Cyclin A1, Cyclin A2

Cyclin B

TF101001

Cyclin B1, Cyclin B2

Cyclin D

TF101004

Cyclin D1, Cyclin D2, Cyclin D3

Cyclin E

TF101005

Cyclin E1, Cyclin E2

Cyclin G

TF101007

Cyclin G1, Cyclin G2

Cyclin I

TF101007

Cyclin I, Cyclin I2

Cyclin J

TF101009

Cyclin J, Cyclin J-like protein

Cyclin L

TF101011

Cyclin L1, Cyclin L2

Cyclin M

TF101012

Cyclin M1, Cyclin M2, Cyclin M3, Cyclin M4

Cyclin T

TF101014

Cyclin T2, Cyclin T2


aAll cyclin subfamilies are represented by two to four vertebrate-specific paralogs. Cyclins A, B and D are key cell cycle regulators. Cyclin D provides the link between the cell cycle and the signal transduction machinery.

Huminiecki and Heldin BMC Biology 2010 8:146   doi:10.1186/1741-7007-8-146

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