BMC Biology

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A metabolic signature of long life in Caenorhabditis elegans

Silke Fuchs, Jacob G Bundy, Sarah K Davies, Jonathan M Viney, Jonathan S Swire and Armand M Leroi*

BMC Biology 2010, 8:14 doi:10.1186/1741-7007-8-14

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A metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans

Cecilia Castro, Funda Sar, W Robert Shaw, Masanori Mishima, Eric A Miska, Julian L Griffin BMC Genomics 2012, 13:36 (20 January 2012)

Research article   Open Access

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

Kristel Brys, Natascha Castelein, Filip Matthijssens, Jacques R Vanfleteren, Bart P Braeckman BMC Biology 2010, 8:91 (28 June 2010)

A mutation in the insulin/IGF-1-like receptor doubles the lifespan of C. elegans, but it is not known how. Bart Braeckman and colleagues now find that the mutation arrests the age-dependent decline in mitochondrial function.

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Regulation of metabolism in Caenorhabditis elegans longevity

Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010)

A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.