A metabolic signature of long life in Caenorhabditis elegans
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* Corresponding author: Armand M Leroi a.leroi@imperial.ac.uk
- Equal contributors
BMC Biology 2010, 8:14 doi:10.1186/1741-7007-8-14
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BioMed Central: 3 citations
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Cecilia Castro, Funda Sar, W Robert Shaw, Masanori Mishima, Eric A Miska, Julian L Griffin BMC Genomics 2012, 13:36 (20 January 2012) |
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Kristel Brys, Natascha Castelein, Filip Matthijssens, Jacques R Vanfleteren, Bart P Braeckman BMC Biology 2010, 8:91 (28 June 2010) A mutation in the insulin/IGF-1-like receptor doubles the lifespan of C. elegans, but it is not known how. Bart Braeckman and colleagues now find that the mutation arrests the age-dependent decline in mitochondrial function.
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Regulation of metabolism in Caenorhabditis elegans longevity Marco Gallo, Donald L Riddle Journal of Biology 2010, 9:7 (10 February 2010) A metabolomic quest for universals in the control of lifespan recently reported in BMC Biology implicates branched-chain amino acid pools. Gallo and Riddle review the lessons from C.elegans in research on longevity, and discuss the implications of the metabolomic research.
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