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Open Access Highly Accessed Commentary

Kinesin-14: the roots of reversal

Robert A Cross

Author affiliations

Centre for Mechanochemical Cell Biology, Warwick University Medical School, Gibbet Hill, Coventry CV4 7AL, UK

Citation and License

BMC Biology 2010, 8:107  doi:10.1186/1741-7007-8-107

Published: 16 August 2010


Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.

See research article: webcite