Vertebrate Hedgehog signaling: cilia rule
1 Tumour Biology and Angiogenesis Department, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA
2 Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology, the Liver Center, Cardiovascular Research Institute and Diabetes Center, University of California, San Francisco, CA 94158, USA
BMC Biology 2010, 8:102 doi:10.1186/1741-7007-8-102Published: 29 July 2010
The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction.