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Vertebrate Hedgehog signaling: cilia rule

Christopher W Wilson1* and Didier YR Stainier2

Author Affiliations

1 Tumour Biology and Angiogenesis Department, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA

2 Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology, the Liver Center, Cardiovascular Research Institute and Diabetes Center, University of California, San Francisco, CA 94158, USA

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BMC Biology 2010, 8:102  doi:10.1186/1741-7007-8-102

Published: 29 July 2010


The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction.

See research article: webcite