Table 1

Candidate Genes for Alcohol Consumption by HXB/BXH RI Rats.

Gene Symbol

Gene Description

Gene Location Chr(Mb)

eQTL Location Chr(Mb)

eQTL Mb Range

eQTL LOD (p-value)

bQTL Location Chr(Mb)

Correlation Coefficient (p-value)

Broad Sense Heritability

Percent Present


Cckbr

cholecystokinin B receptor

1 (163.17)

1 (168.95)

139.73-179.97

6.3 (<0.001)

1 (159-194)

0.61 (0.0023)

0.82

100%



Coq7

demethyl-Q 7 (Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7)

1 (176.76)

1 (177.64)

152.25-179.75

9.0 (<0.001)

0.55 (0.0059)

0.93

100%



Fgfr2

fibroblast growth factor receptor 2 isoform c

1 (189.48)

1 (184.63)

173.38-184.63

20.7 (<0.001)

0.58 (0.0029)

0.99

93%



Ptpre

protein tyrosine phosphatase receptor type E

1 (195.16)

1 (195.13)

184.63-196.57

13.1 (<0.001)

-0.43 (0.0348)

0.95

100%



Abat

4-aminobutyrate aminotransferase

10 (7.04)

1 (132.04)

12.84-249.11

4.2 (0.027)

-0.51 (0.0267)

0.56

100%



Tpst1

tyrosylprotein sulfotransferase 1 (predicted)

12 (27.59)

1 (15.55)

9.02-205.67

3.1 (0.096)

0.51 (0.0265)

0.54

99%


Tmem2

transmembrane protein 2

1 (225.04)

1 (223.19)

39.64-254.91

3.7 (0.065)

1 (213-238)

0.53 (0.0095)

0.85

100%


Mboat2

membrane bound O-acyltransferase domain

6 (42.49)

6 (38.84)

18.53-131.90

3.5 (0.072)

6 (33-53)

0.43 (0.0455)

0.73

100%



Dynlrb1

dynein light chain roadblock-type 1

3 (145.72)

6 (38.84)

18.53-115.00

3.6 (0.095)

0.44 (0.0456)

0.66

100%



Tnk2

tyrosine kinase, no-receptor, 2

11 (69.93)

6 (25.68)

0.27-38.84

4.0 (0.010)

-0.50 (0.0212)

0.68

100%



Nek3

NIMA (never in mitosis gene a)-related expressed

16 (74.52)

6 (37.98)

25.56-37.98

4.1 (0.008)

-0.43 (0.0499)

0.69

97%



Afap1l1

actin filament associated protein 1-like 1

18 (57.71)

6 (33.80)

25.68-50.93

3.3 (0.090)

0.49 (0.0227)

0.74

100%



Mc4r

melanocortin 4 receptor

18 (63.39)

6 (33.80)

33.80-50.93

3.7 (0.006)

0.46 (0.0417)

0.59

96%



Tubb6

tubulin beta 6

18 (63.92)

6 (33.80)

33.80-124.56

3.2 (0.097)

0.47 (0.0344)

0.63

98%



Spire1

spire homolog 1

18 (64.02)

6 (33.80)

18.53-98.70

3.4 (0.025)

0.53 (0.0109)

0.77

100%


Mogat2

monoacyglycerol O-acyltransferase 2

1 (156.52)

12 (34.31)

29.92-38.52

3.5 (0.028)

12 (25-46)

-0.45 (0.0353)

0.78

98%



F2rl1

proteinase-activated receptor-2 G protein coupled

2 (25.89)

12 (38.52)

36.18-43.30

2.8 (0.059)

0.53 (0.0224)

0.52

52%



P2rx4

P2X purinoceptor 4 (ATP receptor)

12 (34.94)

12 (34.50)

13.40-34.50

5.1 (0.003)

-0.70 (0.0004)

0.80

100%



Rab35

RAB35 member RAS oncogene family

12 (42.23)

12 (41.98)

38.21-43.30

9.0 (<0.001)

0.45 (0.0296)

0.91

100%



Pop5

processing of precursor 5 ribonuclease P/MRP

12 (42.64)

12 (41.98)

36.18-43.30

4.4 (0.025)

-0.54 (0.0125)

0.68

100%


All transcripts listed displayed an eQTL/bQTL overlap, showed a significant correlation with alcohol consumption, and passed the filters for heritability and detectability of expression.

Tabakoff et al. BMC Biology 2009 7:70   doi:10.1186/1741-7007-7-70

Open Data