Major ionisation zones in the pH-dependence of protein stability. A schematic diagram of the major ionisation regions in a plot of folding stability (ΔGFU) versus pH. Properties describing this pH-dependence, in the notional case of no protein unfolding over the pH range, are shown. Cysteine and tyrosine have been omitted from this figure since they are mostly unionised at physiological pH.
Chan and Warwicker BMC Biology 2009 7:69 doi:10.1186/1741-7007-7-69