Table 1

Levels of c-Myc targets involved in ribosome biogenesis and translation

Targets

Relative expressiona


L2.5

L5.5



Mu-1

Mu-2

Mu-3

Mu-4


RNA Pol II productsb

Nucleolar proteins

Nucleophosmin

0.62

0.78

0.59

0.39

Nucleolin

0.58

0.93

0.65

0.26

Large ribosomal proteins

L3

0.47

0.77

0.40

0.24

L6

0.56

1.08

0.44

0.32

L11

0.62

0.97

0.37

0.33

L23

0.73

0.59

0.36

0.25

Small ribosomal proteins

S3

0.46

0.55

0.60

0.22

S19

0.49

0.83

0.45

0.18

Other

Poly(A)-binding protein

0.60

0.73

0.74

0.56

RNA Pol I product

5'-external transcribed spacer of 45S pre-rRNA

0.53

1.19

0.29

0.79

RNA Pol III product

5S rRNA

3.08

0.41

0.28

0.38


aResults are relative expression levels in mutant mice compared with levels in the corresponding wild type (WT) littermates. Four mutant mice (Mu-1 to -4) were analyzed on lactation day 2.5 and 5.5 and each value is relative to the matched WT value. bDirect targets of transcription activated by c-Myc, chosen from http://www.myc-cancer-gene.org/index.asp webcite[46].

Stoelzle et al. BMC Biology 2009 7:63   doi:10.1186/1741-7007-7-63

Open Data