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Prion infection increased the amounts of free cholesterol in neuronal cell lines. The amounts of total cholesterol, free cholesterol and esterified cholesterol (ng cholesterol/mg protein) in extracts from prion infected neuronal cells (ScN2a or ScGT1 cells) compared with their non-infected counterparts (N2a or GT1 cells). Values shown are the mean ± SD from 11 samples. |
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| Cholesterol (ng/mg protein) |
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| Esterified |
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| Total (mean ± SD) |
Free (mean ± SD) |
Mean ± SD |
Percentage |
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| N2a |
472 ± 47 |
384 ± 37 |
87 ± 19 |
18 ± 4 |
| ScN2a |
525 ± 34 |
473 ± 41 |
52 ± 14 |
10 ± 3 |
| GT1 |
453 ± 72 |
368 ± 59 |
85 ± 28 |
19 ± 5 |
| ScGT1 |
542 ± 44 |
500 ± 54 |
42 ± 14 |
8 ± 3 |
Bate et al. BMC Biology 2008 6:8 doi:10.1186/1741-7007-6-8 |
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