|
Enrichment analysis of housekeeping and three selected tissue-specific gene sets. |
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| Housekeeping |
Retina |
Testis |
Adrenal Gland |
|
|
|
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| Canonical pathways maps |
Oxidative phosphorylation |
Visual perception |
CREM signaling in testis |
Tyrosine metabolism (dopamine) |
| Ubiquinone metabolism |
CREB pathway |
Glycolysis and gluconeogenesis |
Catecholamine metabolism |
|
| Cytoskeleton remodeling |
TGF, WNT and cytoskeletal remodeling |
ATM/ATR regulation of G2/M checkpoint |
Estrogen biosynthesis |
|
| Formation of Sin3A and NuRD complexes and their role in transcription regulation |
Regulation of CDK5 in CNS |
Role of APC in cell cycle regulation |
Cortisone biosynthesis and metabolism |
|
| TGF, WNT and cytoskeleton remodeling |
Role of Nek in cell cycle regulation |
Rap1A regulation pathway |
Androstenedione and testosterone biosynthesis and metabolism |
|
| Regulation activity of EIF4F |
Plasmin signaling |
Androgen receptor nuclear signaling |
Non-genomic (rapid) action of androgen receptor |
|
| WNT signaling pathway |
Receptor-mediated HIF regulation |
Insulin regulation of fatty acid metabolism |
Androgen receptor nuclear signaling |
|
| Role of tetraspanins in the integrin-mediated cell adhesion |
Sphingolipid metabolism |
Rap1B regulation pathway |
WNT signaling pathway |
|
| BAD phosphorylation |
Retinol metabolism |
Nucleocytoplasmic transport of CDK/Cyclins |
TGF, WNT and cytoskeletal remodeling |
|
| TCA |
Regulation activity of EIF2 |
Estrogen biosynthesis |
||
| GeneGo processes |
Translation_Translation initiation |
Signal transduction_Visual perception |
Reproduction_Spermatogenesis |
Transport_Potassium transport |
| Translation_Elongation-Termination |
Transmission of nerve impulse |
Cell cycle_Meiosis |
Cell adhesion cadherins |
|
| Transcription_mRNA processing |
Reproduction_GnRH signaling pathways |
Signal transduction_CREM pathway |
Development neurogenesis in general |
|
| Proteolysis_Ubiquitin-proteasomal proteolysis |
Development_Neurogenesis in general |
Reproduction_Male sex differentiation |
Signal transduction NOTCH signaling |
|
| Translation_Regulation of initiation |
Transport_Calcium transport |
Signal transduction_Androgen receptor nuclear signaling |
Signal transduction_Androgen receptor signaling cross talk |
|
| Protein folding_Folding in normal condition |
Development_Neurogenesis- synaptogenesis |
Cell cycle_Mitosis |
Signal transduction_CREM pathway |
|
| Immune_Phagosome in antigen presentation |
Reproduction_Progesterone signaling |
Proteolysis_Ubiquitin-proteasomal proteolysis |
Signal transduction_Neuropeptides signaling pathway |
|
| Protein folding_Protein folding nucleus |
Cell adhesion_Integrin priming |
Cell cycle_Core |
Development ossification and bone remodeling |
|
| Protein folding_Response to unfolded protein |
Translation_Regulation of initiation |
Signal transduction_Visual perception |
Muscle contraction |
|
| Protein folding_ER and cytoplasm |
Reproduction_Male sex differentiation |
Cell cycle_G2-M |
Cell adhesion amyloid proteins |
|
| GO processes |
Metabolic process |
Sensory perception of light stimulus |
Sexual reproduction |
Feeding behavior |
| Cellular metabolic process |
Visual perception |
Reproduction |
Smooth muscle differentiation |
|
| Translation |
Sensory perception |
Spermatogenesis |
Oocyte development |
|
| Macromolecule metabolic process |
Neurological process |
Male gamete generation |
Oogenesis |
|
| Primary metabolic process |
Detection of visible light |
Gametogenesis |
Male gonad development |
|
| Macromolecule biosynthetic process |
Detection of light stimulus |
Fertilization |
Embryonic epithelial tube formation |
|
| Cellular protein metabolic process |
Detection of abiotic stimulus |
Sperm motility |
Development of primary male sexual characteristic |
|
| Cellular macromolecule metabolic process |
Phototransduction |
Spermatid development |
Germ cell development |
|
| Protein metabolic process |
Detection of light stimulus during visual perception |
Spermatid differentiation |
Cell-cell signaling |
|
| Intracellular transport |
Detection of light stimulus during sensory perception |
Development of primary sexual characteristics |
Dopamine biosynthetic process from tyrosine |
|
| Diseases |
Neoplasm by site |
Vision disorder |
Infertility |
Diabetes insipidus |
| Breast neoplasms |
Eye diseases |
Infertility, male |
Hypopituitarism |
|
| Breast disease |
Retinal degeneration |
Dyskeratosis congenita |
Adrenal gland disease |
|
| Genetic disease, inborn |
Sensation disorders |
Dysautonomia, familial |
Adrenal cortex disease |
|
| Digestive systems neoplasm |
Night blindness |
Ciliary motility disorders |
Adrenal cortex neoplasm |
|
| Poxviridae infections |
Retinitis pigmentosa |
Kartagener Syndrome |
Adrenal gland neoplasm |
|
| Lysosomal storage disease |
Eye diseases, hereditary |
Dextrocardia |
Carcinoma, basal cell |
|
| Mental retardation |
Retinal diseases |
Herpes zoster |
Neoplasm, basal cell |
|
| Aneuploidy |
Blindness |
Bronchiectasis |
Myokymia |
|
| Vaccinia |
Retinitis |
Autonomic nervous system diseases |
Pathologic processes |
|
|
Gene set enrichment with canonical maps, GeneGo processes, gene ontology processes and diseases was performed. | ||||
Dezső et al. BMC Biology 2008 6:49 doi:10.1186/1741-7007-6-49 |
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