Additional file 2.

Principal Component Analysis (PCA) of expression of all genes in ovary (A) and testis (B) of mice from 1 to 24 months old on ad libitum (AL) or calorie restriction (CR) diet. In ovary, PC1 is associated with age; PC2 is related to an initial increase of gene expression followed by a decrease in the oldest age; PC3 represents the effect of calorie restriction, which is strongest at the age of 6 months. In testis, PC1 is related to age; PC2 is associated with CR but mostly in the oldest animals. The first two principal components accounted for 58% of variance in testis compared to 74% in ovary, which indicates that PCA patterns for testis were noisier than those for ovary due to very limited changes in gene expression values.

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Sharov et al. BMC Biology 2008 6:24   doi:10.1186/1741-7007-6-24