Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes

doi:10.1186/1741-7007-5-40

BMC Biology

Volume 5

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Ellegren H
Hultin-Rosenberg L
Brunström B
Dencker L
Kultima K
Scholz B

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Dencker L
Kultima K
Scholz B
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Research article

Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes

Hans Ellegren¹ , Lina Hultin-Rosenberg¹ , Björn Brunström² , Lennart Dencker³ , Kim Kultima³ and Birger Scholz³

¹Department of Evolutionary Biology, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden

²Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, SE-752 36 Uppsala, Sweden

³Department of Pharmaceutical Biosciences, Uppsala University, Box 594, SE-751 24 Uppsala, Sweden

author email corresponding author email

BMC Biology 2007, 5:40doi:10.1186/1741-7007-5-40


Published:	20 September 2007

Additional files

Additional file 1:

Number of genes showing sex-biased expression pattern in brain, gonads and heart of chicken embryos at different cut-off levels.

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Additional file 2:

Number of genes showing sex-biased expression in brain, gonads and heart of chicken embryos at different cut-off levels.

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Additional file 3:

Venn diagrams showing the number of genes with sex-biased expression in one or several tissues of chicken embryos. (a) Genes with a fold-change of >1.5 and corrected p < 0.05; (b) genes with a fold-change of >2 and corrected p < 0.05. The total number of unbiased hybridizing genes is shown in the lower right corner.

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Additional file 4:

The relationship between observed male-to-female fold-change in expression level of Z-linked genes in microarray and real-time PCR experiments. Data are from Scholz et al [14].

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Additional file 5:

Level 4–5 gene ontology (GO) terms for biological processes overrepresented among unbiased (fold-change <1.2) Z-linked genes.

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Additional file 6:

Level 3–5 gene ontology (GO) terms for biological processes overrepresented among Z-linked genes showing male-biased expression (>1.5 fold-change, corrected p < 0.05).

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Additional file 7:

Box plots showing median of log₂absolute hybridization intensities in soma per chromosome in (a) females and (b) males. Boxes represent the mid 50% of the data (first to third quartiles) and whiskers extend to the minimum and maximum values that are not outliers (defined as >1.5 times the box length away from first and third quartiles). Data from the Z chromosome is shown in red.

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