Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

doi:10.1186/1741-7007-4-1

BMC Biology

Volume 4

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Research article

Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

David Weinkove¹^,2 , Jonathan R Halstead² , David Gems¹ and Nullin Divecha²

¹Department of Biology, University College London, Gower Street, London WC1E 6BT, UK

²Division of Cellular Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

author email corresponding author email

BMC Biology 2006, 4:1doi:10.1186/1741-7007-4-1


Published:	3 February 2006

Additional files

Additional File 1:

Diagram depicting the life cycle of C. elegans in the presence of food and in response to starvation. The first stage larva hatches from the eggshell. In the presence of food the larva continues through four larval stages until it becomes a fertile adult. If the larva hatches in the absence of food it will enter the L1 diapause without undergoing the cell division cycles that normally occur in the L1 stage. When food is encountered, the larva will re-enter normal development. If there is a lack of food and/or overcrowding at the end of L1, the larva will enter a developmental program that results in entry into the dauer stage, a morphologically distinct alternative to L3. When food is re-encountered, the dauer larvae will enter L4, resuming normal development.

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