Research article
The planetary biology of cytochrome P450 aromatases
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* Corresponding author: Steven A Benner benner@chem.ufl.edu
1 Foundation for Applied Molecular Evolution, 1115 NW 4th Street, Gainesville FL 32601-4256, USA
2 Department of Psychiatry, Duke University Medical Center, Durham, NC 27708, USA
3 Department of Physiology & Biophysics, Medical Sciences & Children's Nutrition Center, University of Arkansas, 1120 Marshall Street, Little Rock AR, 72202, USA
4 Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, 5020 Bergen, Norway
5 Ecology and Evolutionary Biology, Brown University, Providence RI 02912, USA
6 Department of Chemistry, University of Florida, Gainesville FL 32611-7200, USA
BMC Biology 2004, 2:19 doi:10.1186/1741-7007-2-19
Published: 17 August 2004Additional files
Additional File 1:
Illustration of planetary biology. This figure illustrates the concepts of planetary biology as they relate to combining genomic, paleontological, chemical and ecological records to understand the history of the biosphere.
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Additional File 2:
An analysis of silent nucleotide substitutions in vertebrate aromatases. The first five columns from the left indicate the index number of sequence 1 compared with sequence 2, the fraction of sites at conserved two-fold redundant coding systems that are identical (f2), the number of such sites that are conserved (c2), and the number of such sites overall (n2). The remaining columns report analogous data: for silent sites in codon systems where a change at the third nucleotide is silent only if the change is a pyrimidine-pyrimidine transition (f2y, c2y, n2y); in silent sites where a change at the third nucleotide is silent only if the change is a purine-purine transition (f2r, c2r, n2r); for the silent sites at three-fold redundant codon systems (f3, c3, n3); and for the silent sites at four-fold redundant codon systems (f4, c4, n4).
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