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Open Access Highly Accessed Research article

Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity

Mart Krupovic1*, Kira S Makarova2, Patrick Forterre1, David Prangishvili1 and Eugene V Koonin2*

Author Affiliations

1 Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 25 rue du Docteur Roux, 75015 Paris, France

2 National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA

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BMC Biology 2014, 12:36  doi:10.1186/1741-7007-12-36

Published: 19 May 2014

Additional files

Additional file 1:

The file contains Figures S1 to S5 and Tables S1 and S2. Figure S1. Multiple sequence alignments of the two groups of Cas1-solo proteins. Figure S2. Analysis of the casposon terminal inverted repeats and target site duplications. Figure S3. Genomic loci showing the amplification of casposons. Figure S4. Phylogeny of RNA-primed type B DNA polymerases. Figure S5. Phylogeny of Cas1 proteins. Table S1. Major characteristics of bacterial and archaeal casposons. Table S2. Annotation of the casposons.

Format: PDF Size: 2.6MB Download file

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Open Data

Additional file 2:

The file contains the multiple sequence alignment of Cas1 proteins used to generate the phylogenetic trees shown in Figure 1 and Figure S5.

Format: ZIP Size: 16KB Download file

Open Data