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Open Access Review

Shaping the dynamic mitochondrial network

Laura L Lackner

Author Affiliations

Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive Hogan 2-100, Evanston, IL 60208, USA

BMC Biology 2014, 12:35  doi:10.1186/1741-7007-12-35

Published: 27 May 2014

Abstract

In a majority of cell types, mitochondria form highly dynamic, tubular networks. Maintaining the shape of this complex network is critical for both mitochondrial and cellular function and involves the activities of mitochondrial division, fusion, motility, and tethering. Recent studies have advanced our understanding of the molecular mechanisms underlying these conserved activities and their integration with cellular needs.