Shaping the dynamic mitochondrial network
Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive Hogan 2-100, Evanston, IL 60208, USA
BMC Biology 2014, 12:35 doi:10.1186/1741-7007-12-35Published: 27 May 2014
In a majority of cell types, mitochondria form highly dynamic, tubular networks. Maintaining the shape of this complex network is critical for both mitochondrial and cellular function and involves the activities of mitochondrial division, fusion, motility, and tethering. Recent studies have advanced our understanding of the molecular mechanisms underlying these conserved activities and their integration with cellular needs.