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Open Access Highly Accessed Review

Modeling the within-host dynamics of HIV infection

Alan S Perelson* and Ruy M Ribeiro

Author Affiliations

MS K710, Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA

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BMC Biology 2013, 11:96  doi:10.1186/1741-7007-11-96

Published: 3 September 2013

Abstract

The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, the response to drug therapy and the rate of generation of HIV variants that escape immune responses. We show how modeling has revealed many dynamical features of HIV infection and how it may provide insight into the ultimate cure for this infection.