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Open Access Opinion

Mitochondrial network morphology: building an integrative, geometrical view

Susanne M Rafelski

Author Affiliations

Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA

BMC Biology 2013, 11:71  doi:10.1186/1741-7007-11-71

Published: 24 June 2013

Abstract

The morphology of mitochondrial networks is complex and highly varied, yet vital to cell function. The first step toward an integrative understanding of how mitochondrial morphology is generated and regulated is to define the interdependent geometrical features and their dynamics that together generate the morphology of a mitochondrial network within a cell. Distinct aspects of the size, shape, position, and dynamics of mitochondrial networks are described and examples of how these features depend on one another discussed.