Results of assays testing transcriptional regulations of mutant MCPH1s containing mutations at human-specific sites. (A) Results of the E2F4B assay testing the changes of enhancing effect. (B) Results of the p14ARF assay testing the repressing effect. All histograms represent the mean ± SD of at least nine data points, including both biological and technical replicates (* P <0.05,** P <0.01, *** P <0.001, n.s, not significant).
Shi et al. BMC Biology 2013 11:62 doi:10.1186/1741-7007-11-62