Successful modeling of two Free-Modeling (FM) targets by Zhang-Server in CASP10. Blue and red are predicted model and experimental structure, respectively. (a) R0006 (a protein encoded in the genome of Bacteroides thetaiotaomicron, VPI-5482) is a beta protein of 169 residues. The ab initio folding algorithm QUARK generates five models of the highest TM-score = 0.32; based on the QUARK models, the TM-align search identifies a template of TM-score = 0.5, which results in the final submitted model with a TM-score = 0.622 after the I-TASSER refinements. (b) R0007 (the human interleukin-34 protein) is an alpha protein with 161 residues. QUARK generates models of the highest TM-score = 0.43; based on the QUARK models the TM-align search identifies a template of TM-score = 0.48, which results in a final model of TM-score = 0.620 after the I-TASSER refinements.
Zhang and Skolnick BMC Biology 2013 11:44 doi:10.1186/1741-7007-11-44