Open Access Research article

The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling

Roman H Khonsari12*, Maisa Seppala13, Alan Pradel4, Hugo Dutel56, Gaël Clément5, Oleg Lebedev7, Sarah Ghafoor1, Michaela Rothova18, Abigael Tucker1, John G Maisey4, Chen-Ming Fan9, Maiko Kawasaki1, Atsushi Ohazama1, Paul Tafforeau10, Brunella Franco11, Jill Helms12, Courtney J Haycraft13, Albert David14, Philippe Janvier5, Martyn T Cobourne13 and Paul T Sharpe1

Author Affiliations

1 Department of Craniofacial Development and Stem Cell Research, Comprehensive Biomedical Research Center, Dental Institute, King’s College London, London, UK

2 Service de Chirurgie Maxillo-Faciale, Centre Hospitalier Universitaire Hôtel-Dieu, Nantes, France

3 Department of Orthodontics, Dental Institute, King’s College London, Guy’s Hospital, London, UK

4 American Museum of Natural History, New York City, NY, USA

5 CNRS-UMR 7207, Muséum National d’Histoire Naturelle, Paris, France

6 CNRS-UMR 7179, Muséum National d’Histoire Naturelle, Paris, France

7 Paleontological Institute of Russian Academy of Science, Moscow, Russian Federation

8 Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic

9 Department of Embryology, Carnegie Institution of Washington, Baltimore, USA

10 European Synchrotron Radiation Facility, Grenoble, France

11 Department of Pediatrics, Università degli Studi di Napoli Federico II, Naples, Italy

12 Department of Surgery, Stanford University, Palo Alto, CA, USA

13 College of Dental Medicine, Craniofacial Biology, Medical University of South Carolina, Carolina, SC, USA

14 Service de Génétique Clinique, Centre Hospitalier Universitaire Hôtel-Dieu, Nantes, France

For all author emails, please log on.

BMC Biology 2013, 11:27  doi:10.1186/1741-7007-11-27

Published: 28 March 2013

Additional files

Additional file 1:

Head anatomy of the holocephalan Callorhinchus milii. Braincase (grey), cast of endocranial cavity and otic capsules (blue), brain and cranial nerves (green) of the late embryo of the extant holocephalan Callorhinchus milii, rotating from dorsal to ventral view. Three-dimensional virtual reconstruction made from synchrotron microtomography images. The oral opening of the buccohypophyseal canal is visible on the ventral aspect of the chondrocranium. See Figure 7 in the main text for further details.

Format: WMV Size: 18MB Download file

Open Data

Additional file 2:

Head anatomy of the coelacanth Latimeria chalumnae. Three-dimensional reconstruction of the cast of the endocranial cavity (purple), brain (green), inner ear (pink) and notochord (yellow) of the extant coelacanth Latimeria chalumnae, based on obtained from a standard medical computed tomography scan. See Figure 9 in the main text for further details.

Format: WMV Size: 1.6MB Download file

Open Data