Resolution:
standard / ## Figure 2.
Exploration of model parameters to explain the observed stochastic gene expression
for six cellular clones. (A) Relationship between normalized variance (NV) and mean fluorescence intensity (MFI)
for six cellular clones (C1 to C17) stably transfected with a unique copy of the fluorescent
reporter mCherry that was integrated at a different locus in each clone. Black line shows the relationship
NV = 1/MFI. (B) Distributions of the possible chromatin dynamics. For each clone, all 1,087 possible
couples of (1/k; 1/_{on}k) values were plotted, expressed as mean open time (1/_{off}k) and mean closed time (1/_{off}k) for all transcription-translation parameter sets explored analytically in the two-state
model (see Methods). One dot therefore represents one possible analytical solution
for that clone. h, hours; d, days; m, months.
_{on}ViĆ±uelas |