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Open Access Highly Accessed Commentary

Predicting the evolution of antibiotic resistance

Martijn F Schenk1 and J Arjan GM de Visser2*

Author Affiliations

1 Institute for Genetics, University of Cologne, Zulpicher Strasse 47, D-50674, Koln, Germany

2 Laboratory of Genetics, Wageningen University, Droevendaalsesteeg 1, 6708PB, Wageningen, the Netherlands

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BMC Biology 2013, 11:14  doi:10.1186/1741-7007-11-14

Published: 22 February 2013

Abstract

Mutations causing antibiotic resistance are often associated with a cost in the absence of antibiotics. Surprisingly, a new study found that bacteria adapting to increased temperature became resistant to rifampicin. By studying the consequences of the involved mutations in different conditions and genetic backgrounds, the authors illustrate how knowledge of two fundamental genetic properties, pleiotropy and epistasis, may help to predict the evolution of antibiotic resistance.

See research article http://www.biomedcentral.com/1471-2148/13/50 webcite